Process technologies for tomorrow.


Dry Powder Inhalers (DPIs) are a convenient method of delivering respiratory drugs. Traditionally, they are used for treating respiratory diseases like asthma and COPD, but their use has also been tested for the treatment of other diseases like diabetes mellitus. Important factors in the development of DPIs are fast absorbance of the active ingredients into the bloodstream, and reduction of negative effects on the stomach.

Dry Powder Inhalers release a powder on inhalation that contains very fine active ingredients. These active ingredients are mixed with a carrier, generally lactose, to provide cohesion inside the inhaler, and separation on absorption in the lungs. Exact characteristics like these demand very specific mixing requirements: Hosokawa Micron has the solutions.

Powder inhalant blending with the Mini Cyclomix

Cyclomix DPI blenders

Hosokawa Micron has adapted the proven Cyclomix technology specifically with blending DPI formulae in mind. The Cyclomix is able to disperse the active ingredients in the lactose filler exactly, so that the active ingredients will be released during inhalation. It mixes homogeneous batches that require low mixing energy and is gentle enough to eliminate any risk of particle erosion. Its conical construction and central outlet result in complete discharge of the mixing vessel and easy cleaning.

The Cyclomix is suitable for batches of 5 to 2000 litres and can be tailor made to suit your specific customer specifications, including CIP, control systems, variations on charging and discharging. The lab version is called Mini Cyclomix and this model features exchangeable product bowls with volumes of 0.1, 1 or 2 litres. All Cyclomix mixers comply with cGMP standards.



At Intech Biopharm, they are using a 5 litre Cyclomix high shear mixer in their DPI production line to achieve complete mixing for very a small amount of API in a large amount of excipients:
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Cyclomix high shear DPI mixer



Related technologies

Producers of dry powder inhalers may also be interested in these related technologies:

  • Air jet mills from Hosokawa Alpine, for the micronisation of actives and lactose
  • Mechanofusion from Hosokawa Micron Corporation, for particle design
  • Nobilta super high shear mixer


Our test and process development centre in the Netherlands offers unique possibilities for testing your product to determine the most efficient process, system or plant prior to final design. We can provide laboratory-level as well as production-sized trials.

Whether you wish to test a single machine or a complete powder processing system, the same skilled and experienced staff are here to help ensure that your requirements are met, and that you are entirely satisfied with the results.

We offer process equipment and technologies from individual units to large scale bespoke system solutions. Our principle is to deliver high performance yet affordable solutions that meet our customers' demands and long term challenges.


To learn more about our powder process equipment and systems for inhalant powders (DPI), contact us:



Hosokawa Micron B.V. is certified according to ISO 14001. Our certification covers all environmental themes of ISO 14001: air, soil, energy, waste, water, noise and hazardous substances. In addition, Hosawa Micron was awarded an EcoVadis Silver Medal for its sustainability achievements. EcoVadis determined that the company was among the top 15% of companies rated by EcoVadis in the special machinery industry.

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