Dry Powder Inhalants (DPI)

Dry Powder Inhalers (DPIs) are a convenient method of delivering respiratory drugs. Traditionally, they are used for treating respiratory diseases like asthma and COPD, but their use has also been tested for the treatment of other diseases like diabetes mellitus. Important factors in the development of DPIs are fast absorbance of the active ingredients into the bloodstream, and reduction of negative effects on the stomach.

Dry Powder Inhalers release a powder on inhalation that contains very fine active ingredients. These active ingredients are mixed with a carrier, generally lactose, to provide cohesion inside the inhaler, and separation on absorption in the lungs. Exact characteristics like these demand very specific mixing requirements: Hosokawa Micron has the solutions.

Powder inhalant blending with the Mini Cyclomix

Cyclomix DPI blenders

Hosokawa Micron has adapted the proven Cyclomix technology specifically with blending DPI formulae in mind. The Cyclomix is able to disperse the active ingredients in the lactose filler exactly, so that the active ingredients will be released during inhalation. It mixes homogeneous batches that require low mixing energy and is gentle enough to eliminate any risk of particle erosion. Its conical construction and central outlet result in complete discharge of the mixing vessel and easy cleaning.

The Cyclomix is suitable for batches of 5 to 2000 litres and can be tailor made to suit your specific customer specifications, including CIP, control systems, variations on charging and discharging. The lab version is called Mini Cyclomix and this model features exchangeable product bowls with volumes of 0.1, 1 or 2 litres. All Cyclomix mixers comply with cGMP standards.



At Intech Biopharm, they are using a 5 litre Cyclomix high shear mixer in their DPI production line to achieve complete mixing for very a small amount of API in a large amount of excipients:
Click here »


Cyclomix high shear DPI mixer



Related technologies

Producers of dry powder inhalers may also be interested in these related technologies:

Try before you buy

Hosokawa Micron's testing and process development centre in the Netherlands offers unique possibilities for testing your product to determine the most efficient process, system or plant prior to final design. We can provide laboratory-level as well as production-sized trials.

Whether you wish to test a single machine or a complete powder processing system, the same skilled and experienced staff are here to help ensure that your requirements are met, and that you are entirely satisfied with the results.

From pilot plant to production scale

We offer process equipment and technologies from individual units to large scale bespoke system solutions. Our principle is to deliver high performance yet affordable solutions that meet our customers' demands and long term challenges.

How can we help you?

To learn more about our powder process equipment, contact us:

Related Process Equipment

Hosokawa Micron designs and manufactures mixing, drying and agglomeration equipment and systems for the powder and bulk processing industry.

Mini Cyclomix

Learn more

High-shear impact mixer

Learn more

System Solutions

Learn more

Milling & Classifying

Learn more

CIP/SIP cleaning

Learn more